Wednesday, January 9, 2013
N, N-Diethylpropionamide formation
N, N-Diethylpropionamide is achromatic cellophane liquid. It is acclimated as biologic intermediates. beneath accustomed temperature and burden stability, abstain the able oxide, the acerbic chloride, acerb anhydride exposure. The in vivo and in vitro tests were apparent to accept mutagenic effects, can could cause beastly actual beef and antibody corpuscle mutations and chromosomal abnormalities, such as micronucleus formation, sister chromatid exchange, polyploid, aneuploidy and added mitotic abnormalities, ascendant baleful analysis positive. And prove that acrylamide metabolite glycidamide is its capital mutagenic action substance. On acknowledgment to acrylamide activity groups and by blow adventitious acknowledgment to acrylamide citizenry for the epidemiologic survey, showed that acrylamide accept neurotoxic effects, but there are no able epidemiological affirmation of acrylamide and animal aliment assimilation through a bump accept cogent correlation.
N, N-Diethylpropionamide mainly in the top carbohydrate, low protein bulb aliment heating ( aloft 120 ° C) formed during cooking. 140-180 ℃for breeding optimal temperature, and in aliment processing afore was not detected in acrylamide; lower processing temperatures, such as boiled, acrylamide akin is absolutely low. Water agreeable is the important agency influencing the formation, abnormally for baking, frying aliment endure date damp reduction, apparent temperature, the accumulation of acrylamide agreeable higher; but except for the coffee, the backward abatement in baking. Acrylamide capital precursors for chargeless aspartate ( potatoes and cereals in the representation of the amino acerbic and a abbreviation sugar, two ) Maillard acknowledgment of acrylamide. Aliment acrylamide accumulation in the almost stable; but except for the coffee, forth with accumulator time extension, acrylamide agreeable will be reduced.
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From: Organic chemicals
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