Lithium sulfate anhydrous pharmacological effects

Lithium sulfate (Lithium sulfate anhydrous), also known as glutamic acid lithium. Colorless monoclinic crystal or white crystalline powder, soluble in water, insoluble in acetone and ethanol. 25 ° C, when the water solubility of 25.7%. With α, β, γ three crystal type. α-type white monoclinic crystal, β-type crystal is hexagonal, γ-type cubic crystal. Hygroscopicity. Crystallized from the concentrated aqueous solution of lithium sulphate monohydrate is stable. There are treatment of manic depressive psychosis role.
Pharmacological effects:
Lithium sulfate anhydrous mechanism of action has not been fully elucidated, experimental materials that reason salt can inhibit noradrenergic and dopaminergic nerve endings release of neurotransmitters, increasing presynaptic reuptake of neurotransmitters, and to the postsynaptic membrane decreased receptor sensitivity, and thus relieve the symptoms of mania. In addition, it can promote the synthesis of 5-HT, the brain 5-HT and its metabolite increased, so that tends to balance brain neurotransmitters. This not only helps to eliminate the symptoms of affective disorders, but also to help prevent recurrence. The changes that may be induced in vivo by certain lithium salt electrolyte (calcium, potassium, magnesium) and external distribution of cells changes in the nervous cell permeability, and changes in synaptic function achieved. Has not been determined. According to the study speculated that the drug has a stable emotional effect, which is probably because lithium-ion effect of potassium and sodium ions adenosine triphosphate activity, resulting in nerve cell membrane sodium ions between the original conversion function improved, leading to decreased catecholamine neurotransmitters caused. Some people think that lithium salts inhibit adenylate cyclase and reduce ring acid adenosine content, thereby reducing the sensitivity of dopamine receptors, resulting in efficacy. In addition, lithium can still promote the 5 - HT synthesis, the 5 - to increase serotonin levels, but also help stabilize mood.

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